Are you as excited about the September 27th premiere of Season 4 of "Grey's Anatomy" as I am? It's gonna be so different with Meredith and McDreamy kind of split up. It'll also be different without Isaiah Washington's character, Burke, but they've seemed to move on just fine. Notice the new promo picture above, minus Isaiah. Patrick Dempsey commented about the mood on the set. Here's the 411, courtesy of People Magazine:

The actor tells Extra that his 6-month-old twin sons "are developing beautifully ... It's a lot of fun."

It's a sentiment he echoes when asked about filming the latest installment of his hit TV show: "It's a lot lighter, people are having more fun."

"The energy and the adjustments make a big difference," he says, referring to the departure of Isaiah Washington after an on-set altercation between the stars last season.

Definitely pumped to be back at Seattle Grace, he declares, "I'm going to go save some lives again!"

Check out the promo video for ABC's premiere week...

 By the way, I'll be throwing a "Grey's Anatomy"/"Ugly Betty" viewing party at Planet Hollywood for the season premiere September 27th.  You wanna go?  Click below...

SHELLEY'S WADE'S "GREY'S ANATOMY VIEWING PARTY!